How it works

OncInsights is Intervention Insights’ medical information service that combines cutting edge bioinformatics tools with disease insight to specify targeted drugs to help community oncologists develop informed treatment plans for their patients.

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OncInsights™

OncInsights is Intervention Insights’ medical information service to assist physicians in developing personalized treatments for their patients.

• Molecularly targeted therapies and active clinical trials best matching the patient’s unique cancer profile
• Analytical methods used, along with informative scoring metrics for each therapeutic intervention
• Information links to the scientific lines of evidence used to develop the results of the analysis
• Access to scientific literature evidence to support conversations with third-party payers for off-label use of therapies
• Multiple methods for contacting our clinician support team to answer questions about the report

Analytical Methods

The OncInsights service uses a bioinformatics platform to generate custom reports.

Currently the bioinformatics platform uses four unique methods for analyzing the different data sources and developing a predicted therapeutic regimen:

• Molecular Expression Profiling
  Allows OncInsights to molecularly profile a patient’s unique disease based on genomic expression. This method is often the sole method used by our competitors.
• Molecular Connectivity Map
  Created by the Broad Institute (MIT and Harvard Partnership), this method generates a detailed map that links gene patterns associated with disease to corresponding patterns produced by drug candidates while overlaying a variety of genetic manipulations. This map allows researchers to screen compounds against genome-wide disease signatures, rather than a pre-selected set of target genes. Drugs are paired with diseases using sophisticated pattern-matching with a high level of resolution and specificity.
• Oncology Cell Based Response Analysis
  Developed to leverage the evolving National Cancer Institute’s gene expression and drug response database to correlate the molecular basis of a patient’s disease with documented drug response.
• Weighted Molecular Network Topology Analysis
  Patent-pending method developed by researchers at the Van Andel Research Institute. This method leverages knowledge of biological molecular networks with proprietary statistical strategies for analyzing these networks to identify key intervention points within a patient’s tumor based upon a genomic profile.